Integrated metabolite and gene expression profiles identify lipid biomarkers associated with progression of hepatocellular carcinoma and patient outcomes.

Integrated metabolite and gene expression profiles identify lipid biomarkers associated with progression of hepatocellular carcinoma and patient outcomes.

OBJECTIVE
We combined gene expression and metabolic profile analysis to identify factors associated with the outcomes of patients with hepatocellular carcinoma (HCC).


METHOD
We compared the pattern of metabolism and gene expression between paired tumor and nontumor tissue from 30 patients with HCC, and validated the results using a sample of 356 patients with HCC. A total of 469 metabolites were measured by using chromatography / mass spectrometry spectrometry liquid and gas chromatography / mass. Metabolism and integrated genomic data, and Kaplan-Meier and Cox proportional hazards analysis was used to a certain pattern associate with patient outcomes. related factors were evaluated for their effect on cancer cells in vitro and tumor formation in nude mice.


RESULTS
We identified 28 metabolites and 169 genes associated with aggressive HCC. lipid metabolite-stearoyl-CoA desaturase (SCD) is associated with the aberrant activity of palmitate signal in aggressive HCC samples. The expression of gene products associated with these metabolites, including SCD, was independently associated with survival time and recurrence of tumors in test and validation sets.

The combined expression of SCD and α-fetoprotein associated with outcomes of patients with early-stage liver cancer. Levels of monounsaturated palmitic acid, the product of SCD activity, an increase in aggressive HCCS; monounsaturated palmitic acid increased migration and invasion of HCC cells cultured and colony formation by liver cancer cells. HCC cells expressed small interfering RNA against SCD decreased cell migration and the formation of colonies in culture and reduced tumorigenicity in mice.


CONCLUSION
By using a combination of gene expression and metabolic profile analysis, we identified a network of lipogenic involving SCD and palmitic signal and associated with the development of HCC and patient outcomes. Microarray platform and data that has been submitted to the Gene Expression Omnibus at NCBI public database following the guidelines MIAME. accession numbers: GPL4700 (platform), and GSE6857 (sample).

Integrated metabolite and gene expression profiles identify lipid biomarkers associated with progression of hepatocellular carcinoma and patient outcomes.
Integrated metabolite and gene expression profiles identify lipid biomarkers associated with progression of hepatocellular carcinoma and patient outcomes.

Interferome v2.0: updated database of interferon-regulated genes described.

Interferome v2.0 is an update of an earlier version of DB Interferome NAR published in the 2009 edition of the database. Much better computing infrastructure now allows more complex and faster queries, and supports more data sets of types I, II and III interferon (IFN) -treated cells, rat or human.

Quantitative, MIAME appropriate data is collected, carried out a thorough analysis, standardized, quantitative and statistical and then significant changes in gene expression are uploaded. a comprehensive manual collection of metadata in v2.0 allows flexible, detailed searches capacity including the parameters: range double change, the type of IFN, concentration and time, and cell / tissue types.

JBScreen Classic 6 - 10

M-CS-113L 5 Kits
EUR 885
Description: JBScreen Classic 6 - 10

JBScreen Classic 1 - 10

M-CS-114L 10 Kits
EUR 1644
Description: JBScreen Classic 1 - 10

JBScreen Thermofluor FUNDAMENT HTS

M-CS-332 93 solutions
EUR 326
Description: JBScreen Thermofluor FUNDAMENT HTS

JBScreen Thermofluor SPECIFIC HTS

M-CS-333 93 solutions
EUR 326
Description: JBScreen Thermofluor SPECIFIC HTS

JBScreen Classic 7 (MPD based)

M-CS-107L 24 solutions
EUR 204
Description: JBScreen Classic 7 (MPD based)

JBScreen Classic 10 (Salt based)

M-CS-110L 24 solutions
EUR 204
Description: JBScreen Classic 10 (Salt based)

JBScreen Classic 2 (PEG 4000 based)

M-CS-102L 24 solutions
EUR 204
Description: JBScreen Classic 2 (PEG 4000 based)

JBScreen Classic 3 (PEG 4000+ based)

M-CS-103L 24 solutions
EUR 204
Description: JBScreen Classic 3 (PEG 4000+ based)

JBScreen Classic 6 (Ammonium Sulfate based)

M-CS-106L 24 solutions
EUR 204
Description: JBScreen Classic 6 (Ammonium Sulfate based)

JBScreen Classic 8 (MPD/Alcohol based)

M-CS-108L 24 solutions
EUR 204
Description: JBScreen Classic 8 (MPD/Alcohol based)

JBScreen Classic 9 (Alcohol/Salt based)

M-CS-109L 24 solutions
EUR 204
Description: JBScreen Classic 9 (Alcohol/Salt based)

JBScreen Membrane HTS (1.7ml per well)

M-CS-310 96 solutions
EUR 508
Description: JBScreen Membrane HTS (1.7ml per well)

JBScreen Membrane 1 - 4 & JBScreen Detergents HTS (4 + 1 Kits)

M-CS-308 4 + 1 Kits
EUR 1754
Description: JBScreen Membrane 1 - 4 & JBScreen Detergents HTS (4 + 1 Kits)

JBScreen Classic HTS II L (1.7 ml per well) (Ammonium Sulfate, MPD, Alcohol and Salt based)

M-CS-202L 96 solutions
EUR 309
Description: JBScreen Classic HTS II L (1.7 ml per well) (Ammonium Sulfate, MPD, Alcohol and Salt based)

JBScreen Classic 1 (PEG 400 to 3000 based)

M-CS-101L 24 solutions
EUR 204
Description: JBScreen Classic 1 (PEG 400 to 3000 based)

JBScreen Classic 5 (PEG 8000 to 20000 based)

M-CS-105L 24 solutions
EUR 204
Description: JBScreen Classic 5 (PEG 8000 to 20000 based)

JBScreen Basic HTS L (1.7 ml per well)

M-CS-203L 96 solutions
EUR 309
Description: JBScreen Basic HTS L (1.7 ml per well)

JBScreen Kinase HTS L (1.7 ml per well)

M-CS-204L 96 solutions
EUR 508
Description: JBScreen Kinase HTS L (1.7 ml per well)

JBScreen JCSG++ HTS L (1.7 ml per well)

M-CS-206L 96 solutions
EUR 323
Description: JBScreen JCSG++ HTS L (1.7 ml per well)

JBScreen PACT++ HTS L (1.7 ml per well)

M-CS-207L 96 solutions
EUR 323
Description: JBScreen PACT++ HTS L (1.7 ml per well)

JBScreen Pentaerythritol HTS L (1.7 ml per well)

M-CS-210L 96 solutions
EUR 508
Description: JBScreen Pentaerythritol HTS L (1.7 ml per well)

JBScreen Plus HTS L (1.0 ml per well)

M-CS-507L 96 solutions
EUR 724
Description: JBScreen Plus HTS L (1.0 ml per well)

JBScreen Classic 4 (PEG 5000 MME to 8000 based)

M-CS-104L 24 solutions
EUR 204
Description: JBScreen Classic 4 (PEG 5000 MME to 8000 based)

JBScreen PEG/Salt HTS L (1.7 ml per well)

M-CS-205L 96 solutions
EUR 323
Description: JBScreen PEG/Salt HTS L (1.7 ml per well)

JBScreen Nuc-Pro HTS L (1.7 ml per well)

M-CS-209L 96 solutions
EUR 508
Description: JBScreen Nuc-Pro HTS L (1.7 ml per well)

JBScreen Buffers

M-CS-214 84 solutions
EUR 323
Description: JBScreen Buffers

JBScreen LCP

M-CS-340 4 x 24 solutions
EUR 958
Description: JBScreen LCP

Human Drug Detoxication I

HDTX-I 1 set
EUR 657.6

Human Kinase Library I

HKIN-I 1 set
EUR 540

Mouse Cytokine Primer Library I

MCA-I 1 set
EUR 540

Human Cytokine Primer Library I

HCA-I 1 set
EUR 540

Rat Cytokine Primer Library I

RCA-I 1 set
EUR 657.6

JBScreen Basic 1

M-CS-121 24 solutions
EUR 204
Description: JBScreen Basic 1

JBScreen Basic 2

M-CS-122 24 solutions
EUR 204
Description: JBScreen Basic 2

JBScreen Basic 3

M-CS-123 24 solutions
EUR 204
Description: JBScreen Basic 3

JBScreen Basic 4

M-CS-124 24 solutions
EUR 204
Description: JBScreen Basic 4

JBScreen Kinase 1

M-CS-131 24 solutions
EUR 339
Description: JBScreen Kinase 1

JBScreen Kinase 2

M-CS-132 24 solutions
EUR 339
Description: JBScreen Kinase 2

JBScreen Kinase 3

M-CS-133 24 solutions
EUR 339
Description: JBScreen Kinase 3

JBScreen Kinase 4

M-CS-134 24 solutions
EUR 339
Description: JBScreen Kinase 4

JBScreen JCSG++ 1

M-CS-151 24 solutions
EUR 215
Description: JBScreen JCSG++ 1

JBScreen JCSG++ 2

M-CS-152 24 solutions
EUR 215
Description: JBScreen JCSG++ 2

JBScreen JCSG++ 3

M-CS-153 24 solutions
EUR 215
Description: JBScreen JCSG++ 3

JBScreen JCSG++ 4

M-CS-154 24 solutions
EUR 215
Description: JBScreen JCSG++ 4

JBScreen PACT++ 1

M-CS-161 24 solutions
EUR 215
Description: JBScreen PACT++ 1

JBScreen PACT++ 2

M-CS-162 24 solutions
EUR 215
Description: JBScreen PACT++ 2

JBScreen PACT++ 3

M-CS-163 24 solutions
EUR 215
Description: JBScreen PACT++ 3

JBScreen PACT++ 4

M-CS-164 24 solutions
EUR 215
Description: JBScreen PACT++ 4

JBScreen Buffers Xtreme

M-CS-215 84 solutions
EUR 323
Description: JBScreen Buffers Xtreme

JBScreen Plus Kosmotropic

M-CS-501 24 solutions
EUR 226
Description: JBScreen Plus Kosmotropic

JBScreen Plus Chaotropic

M-CS-502 24 solutions
EUR 226
Description: JBScreen Plus Chaotropic

JBScreen Plus Salts

M-CS-503 24 solutions
EUR 226
Description: JBScreen Plus Salts

JBScreen Plus Additives

M-CS-504 24 solutions
EUR 226
Description: JBScreen Plus Additives

JBScreen Plus Volatiles

M-CS-505 24 solutions
EUR 226
Description: JBScreen Plus Volatiles

JBScreen Detergents 1

M-CS-521 24 solutions
EUR 215
Description: JBScreen Detergents 1

JBScreen Detergents 2

M-CS-522 24 solutions
EUR 215
Description: JBScreen Detergents 2

JBScreen Detergents 3

M-CS-523 24 solutions
EUR 215
Description: JBScreen Detergents 3

JBScreen Detergents 4

M-CS-524 24 solutions
EUR 215
Description: JBScreen Detergents 4

SafeView™ Classic

G108 1.0 ml
EUR 85.2

CELLine Classic CL1000

I90005 PK3
EUR 1017.69

CELLine Classic CL350

I90010 PK5
EUR 1232.81

Mouse DNA Repair Primer Library I

MDRL-I 1 set
EUR 774

Human Colon Cancer Primer Library I

HCCP-I 1 set
EUR 657.6

Human DNA Repair Primer Library I

HDRL-I 1 set
EUR 657.6

Human Drug Transporter I Primer Library

HDTP-I 1 set
EUR 657.6

Human Cancer Driver Gene I Primer Library

HCDG-I 1 set
EUR 774

Human Interferon Type I Signaling Primer Library

HIFN-I 1 set
EUR 657.6

JBScreen Basic 1 - 4

M-CS-125 4 Kits
EUR 667
Description: JBScreen Basic 1 - 4

JBScreen Kinase 1 - 4

M-CS-135 4 Kits
EUR 1109
Description: JBScreen Kinase 1 - 4

JBScreen PEG/Salt 1

M-CS-141 24 solutions
EUR 215
Description: JBScreen PEG/Salt 1

JBScreen PEG/Salt 2

M-CS-142 24 solutions
EUR 215
Description: JBScreen PEG/Salt 2

JBScreen PEG/Salt 3

M-CS-143 24 solutions
EUR 215
Description: JBScreen PEG/Salt 3

JBScreen PEG/Salt 4

M-CS-144 24 solutions
EUR 215
Description: JBScreen PEG/Salt 4

JBScreen JCSG++ 1 - 4

M-CS-155 4 Kits
EUR 705
Description: JBScreen JCSG++ 1 - 4

JBScreen PACT++ 1 - 4

M-CS-165 4 Kits
EUR 705
Description: JBScreen PACT++ 1 - 4

JBScreen Nuc-Pro 1

M-CS-181 24 solutions
EUR 339
Description: JBScreen Nuc-Pro 1

JBScreen Nuc-Pro 2

M-CS-182 24 solutions
EUR 339
Description: JBScreen Nuc-Pro 2

JBScreen Nuc-Pro 3

M-CS-183 24 solutions
EUR 339
Description: JBScreen Nuc-Pro 3

JBScreen Nuc-Pro 4

M-CS-184 24 solutions
EUR 339
Description: JBScreen Nuc-Pro 4

JBScreen Pentaerythritol 1-4

M-CS-195 4 Kits
EUR 1109
Description: JBScreen Pentaerythritol 1-4

Autoclave Classic Media 9L

AUT4515 EACH
EUR 1413.6

Autoclave Classic Media 12L

AUT4517 EACH
EUR 1698.6

Seward Bag Classic Strainer

MIX3108 PK200
EUR 88.92

Stomacher 400 Classic Bags

MIX3175 PK500
EUR 96.9

Qiagen QIAcard FTA Classic

FIL5804 PK100
EUR 453.72

QIAcard Indicating FTA Classic

FIL5806 PK100
EUR 573.42

Classic 25 Necktube Core

TW-D024-9C16 1 UNIT
EUR 55
Description: Classic 25 Necktube Core

LCP Classic Starter Kit

MLCP-CSK-1 1 KIT
EUR 2000
Description: LCP Classic Starter KitContains:20 LCP Classic Sandwich Sets (MLCP-CSS1-1)1 10 μL Syringe (for manual dispensing) (MLCP-10muSYR-1)2 100 μL Syringe (for mixing) (MLCP-100muSYR-1)1 Manual Dispenser (MLCP-PB600-1)1 Symmetrical Mixer Union for LCP (MCLP-SMXU-1)6 short 22 gauge small hub needles (MLCP-HN22-6)1 Monoolien-9, 1g (MLCP-RMO9-1)1 4″ Soft Rubber Brayer (M-CTP-BRY1)1 Wizard Cubic LCP Screen (MLCP-RWCS-1)1 Box (20) MicroMounts: (M2-L18SP-A1)1 Box (20) MicroMounts: (M2-L18SP-A2)40 Reusable bases model B1A-R (GB-B1A-R-40)1 pair serrated end tweezers (TW-1)1 Carbide Scribe (MLCP-CBSC-1)5 replacement scribe tips (MLCP-CBT5)

DNA Topoisomerase I assay reagent Set for HTS (enzyme not included)

DRA1000 1000 assays
EUR 452.05
Description: This product includes the reaction buffer and fluorescence dye H19 for 1000 assays of DNA relaxation reactions in a 96-well plate assay format or 2000 assays in a 384-well assay format.

Human topoisomerase I DNA relaxation assay HTS kit (enzyme not included)

HRA1000 100 assays
EUR 452.05
Description: This product includes 4800 ul of 10 x Buffer HT1, 170 ul of 1500 x Dye H19 and 30 ml of 10 x H19 dilution buffer. It is for 1000 DNA relaxation assays in a 96-well plate format or 2000 assays in a 384-well assay format. Supercoiled DNA and human topo I enzyme can be purchased separately.

JBS Solubility Kit HTS

M-CO-311 95 solutions
EUR 395
Description: JBS Solubility Kit HTS

JBScreen Plus Complete all 5 JBScreen Plus kits for a special price

M-CS-506 5 Kits
EUR 986
Description: JBScreen Plus Complete all 5 JBScreen Plus kits for a special price

JBScreen PEG/Salt 1 - 4

M-CS-145 4 Kits
EUR 705
Description: JBScreen PEG/Salt 1 - 4

JBScreen Nuc-Pro 1 - 4

M-CS-185 4 Kits
EUR 1109
Description: JBScreen Nuc-Pro 1 - 4

WSE-5400-U Printgraph Classic

2305401 1unit
EUR 9438
Description: M ai n uni t , Cont r ol , U V

WSE-5400-UP Printgraph Classic

2305403 1unit
EUR 12178.8
Description: M ai n uni t , Cont r ol , U V, Ther mal Pr i nt er

WSE-5400-CyP Printgraph Classic

2305407 1unit
EUR 12836.4
Description: M ai n uni t , Cont r ol , CyanL ED, Ther mal Pr i nt er

Classic CRISPR sgRNA Synthesis Kit

K1252-25 25 Reactions
EUR 526.8
Description: Classic CRISPR sgRNA Synthesis Kit

LEEC C100 Classic Incubator 100L

INC1900 EACH
EUR 2158.02

NBS Shaker Incubator Classic E24

SHA4306 EACH
EUR 7846.62

NBS Shaker Incubator Classic E24R

SHA4307 EACH
EUR 10695.48

NBS Shaker Incubator Classic E25

SHA4308 EACH
EUR 13425.78

NBS Shaker Incubator Classic E25R

SHA4310 EACH
EUR 16126.44

Pipetman Classic 4 Pipette Kit

F167380 EACH
EUR 950.76

Qiagen QIAcard FTA Classic Cards

WB120305 PK25
EUR 145.92

Qiagen QIAcard FTA Indicating Classic

WB120306 PK25
EUR 186.96

Qiagen QIAcard FTA Classic Cards

WHAWB120205 PK100
EUR 485.64

JBScreen Pentaerythritol 1 (PEP 426 based)

M-CS-191 24 solutions
EUR 339
Description: JBScreen Pentaerythritol 1 (PEP 426 based)

JBScreen Pentaerythritol 2 (PEP 629 based)

M-CS-192 24 solutions
EUR 339
Description: JBScreen Pentaerythritol 2 (PEP 629 based)

JBScreen Pentaerythritol 3 (PEE 270 based)

M-CS-193 24 solutions
EUR 339
Description: JBScreen Pentaerythritol 3 (PEE 270 based)

JBScreen Pentaerythritol 4 (PEE 797 based)

M-CS-194 24 solutions
EUR 339
Description: JBScreen Pentaerythritol 4 (PEE 797 based)

JBScreen Membrane 4 (MPD, & Salt based)

M-CS-304L 24 solutions
EUR 339
Description: JBScreen Membrane 4 (MPD, & Salt based)

Astell Classic 33L Autoclave Front Loading

AUT4400 EACH
EUR 10066.2

Astell Classic 43L Autoclave Front Loading

AUT4402 EACH
EUR 11667.9

Astell Classic 63L Autoclave Front Loading

AUT4404 EACH
EUR 13754.1

Astell Classic 63L Autoclave Top Loading

AUT4406 EACH
EUR 13754.1

Hirschmann Dispenser Ceramus Classic 1-5ml

DIS2524 EACH
EUR 443.46

Hirschmann Dispenser Ceramus Classic 2-10ml

DIS2526 EACH
EUR 491.34

Hirschmann Dispenser Ceramus Classic Fixed 1ml

DIS2572 EACH
EUR 406.98

Hirschmann Dispenser Ceramus Classic Fixed 2ml

DIS2574 EACH
EUR 406.98

Hirschmann Dispenser Ceramus Classic Fixed 5ml

DIS2576 EACH
EUR 501.6

Hirschmann Dispenser Ceramus Classic Fixed 10ml

DIS2578 EACH
EUR 417.24

Hirschmann Dispenser Ceramus Classic Fixed 25ml

DIS2580 EACH
EUR 544.92

Petri dish 90mm TV Classic Sterilin

PET2002C PK500
EUR 157.32

Worthington Industries Classic 25 Roller Base

TW-D024-8C02 1 UNIT
EUR 350
Description: Worthington Industries Classic 25 Roller Base

Classic 25 Liquid Dewar (25 Liters)

TW-LD25C 25 liter
EUR 1305
Description: Classic 25 Liquid Dewar (25 Liters)

LCP Classic Sandwich Set (20 sets)

MLCP-CSS1-1 20 SETS
EUR 393
Description: LCP Classic Sandwich Set (20 sets)

AXYPREP FRAGMENTSELECT-I KIT- 1 ML - (SAMPLE SIZE)

MAG-FRAG-I-1 1/pk
EUR 76.8
Description: Bioscience Mag Beads; Magnetic Fragment Select

AXYPREP FRAGMENTSELECT-I KIT- 250 ML - 1900 PREPS

MAG-FRAG-I-250 1/pk
EUR 2343.6
Description: Bioscience Mag Beads; Magnetic Fragment Select

AXYPREP FRAGMENTSELECT-I KIT- 5 ML - 4 PREPS

MAG-FRAG-I-5 1/pk
EUR 189.6
Description: Bioscience Mag Beads; Magnetic Fragment Select

AXYPREP FRAGMENTSELECT-I KIT- 50 ML - 380 PREPS

MAG-FRAG-I-50 1/pk
EUR 790.8
Description: Bioscience Mag Beads; Magnetic Fragment Select

JBScreen Membrane 1-4 - All 4 kits

M-CS-309 4 Kits
EUR 1109
Description: JBScreen Membrane 1-4 - All 4 kits

Steady-Luc Firefly HTS Assay Kit (Lyophilized)

30028-L1 120TST
EUR 166.8
Description: Minimum order quantity: 1 unit of 120TST

Steady-Luc Firefly HTS Assay Kit (Lyophilized)

30028-L2 1000TST
EUR 732
Description: Minimum order quantity: 1 unit of 1000TST

Steady-Luc Firefly HTS Assay Kit (Lyophilized)

30028-L3 10000TST
EUR 3774
Description: Minimum order quantity: 1 unit of 10000TST

Nitric Oxide Cell-Based HTS Assay Kit

K979-100
EUR 783.6

Caspase-3 DEVD-R110 Fluorometric HTS Assay Kit

30009-1 1KIT
EUR 120
Description: Minimum order quantity: 1 unit of 1KIT

Caspase-3 DEVD-R110 Fluorometric HTS Assay Kit

30009-2 1KIT
EUR 271.2
Description: Minimum order quantity: 1 unit of 1KIT

Caspase-3 DEVD-R110 Fluorometric HTS Assay Kit

30009-3 1KIT
EUR 970.8
Description: Minimum order quantity: 1 unit of 1KIT

Caspase-8 IETD-R110 Fluorometric HTS Assay Kit

30012-1 1KIT
EUR 120
Description: Minimum order quantity: 1 unit of 1KIT

Caspase-8 IETD-R110 Fluorometric HTS Assay Kit

30012-2 1KIT
EUR 429.6
Description: Minimum order quantity: 1 unit of 1KIT

Caspase-8 IETD-R110 Fluorometric HTS Assay Kit

30012-3 1KIT
EUR 1952.4
Description: Minimum order quantity: 1 unit of 1KIT

Steady-Luc Firefly HTS Assay Kit (12 ml)

30028-1 1KIT
EUR 166.8
Description: Minimum order quantity: 1 unit of 1KIT

Steady-Luc Firefly HTS Assay Kit (100 ml)

30028-2 1KIT
EUR 732
Description: Minimum order quantity: 1 unit of 1KIT

Steady-Luc Firefly HTS Assay Kit (10x100 ml)

30028-3 1KIT
EUR 3774
Description: Minimum order quantity: 1 unit of 1KIT

HTS Transwell-96 Reservoir Plate Not Treated Sterile

3383 PK10
EUR 90.06

HTS Transwell-24 Clear Not Treated Reservoir Sterile

3395 PK48
EUR 344.28

Pi-minimal Screen HTS (1.7 ml per well)

M-CS-211L 96 solutions
EUR 508
Description: Pi-minimal Screen HTS (1.7 ml per well)

Pi-PEG Screen HTS (1.7 ml per well)

M-CS-212L 96 solutions
EUR 508
Description: Pi-PEG Screen HTS (1.7 ml per well)

JBScreen Membrane 3 (Ammonium Sulfate, Alcohol and Salt based)

M-CS-303L 24 solutions
EUR 339
Description: JBScreen Membrane 3 (Ammonium Sulfate, Alcohol and Salt based)

SafeFAST Classic 209 D Class II Microbiological Safety Cabinet

CAB1416 EACH
EUR 9226.02

There is no limit to the number of genes that can be used to search the database in one query. secondary analysis such as gene ontology, regulatory factors, the location of the plot chromosome or tissue expression of IFN-regulated genes (IRGs) can be done in Interferome v2.0, or data can be downloaded in text format that is readily compatible with the common secondary analysis program. Given the importance of IFN to the innate immune response in infectious, inflammatory diseases and cancer, this upgrade of Interferome to version 2.0 will facilitate the identification of signatures of genes important in the pathogenesis of this disease.

Trevor

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