BACKGROUND
public sharing of scientific data have been assumed to be more important in the era of omics. Transparency is needed for confirmation and validation, and some help inspectors in extracting the maximum value from large data sets. Thus, the filing of the database and the provision of the Minimum Information About Microarray Experiment (MIAME) (3) required by most journals as a prerequisite for review or acceptance.

METHOD
In this study, the rate of submission of the data and compliance MIAME reviewed for 127 articles were included based microarray microRNA (miRNA) profiling and published from July 2011 until April 2012 in the journal that published the largest number of such articles – PLoS ONE, the Journal of Biological Chemistry, Blood and Oncogenes – along with articles from other journals 9, including Clinical Chemistry, that the smaller number of articles published array-based.

RESULTS
Overall, the submission of data reported in the publication for <40% of all articles, and nearly 75% of the articles were MIAME obedient. On average, the article which includes full data submission scored significantly higher on a quality metric of articles with limited or no data submission, and studies with an adequate description of the proportional method including a larger number of repeat experiments. Finally, some articles are not MIAME compliant, data reanalysis reveals less than full support for the conclusions published, in one case leading to the retraction.

CONCLUSION
These findings angle hypothesis that the reluctance to share data related to the low quality studies and investigations showed that the majority of miRNA arrays underpowered and / or potentially compromised by the lack of appropriate reporting and data submission.

DeltaNp63 different isoforms regulate gene expression in squamous cell carcinoma: identification of Cox-2 as a new p63 targets.

P53 homologue of p63 produced six different isoforms that are important in the development of epithelial tissues and squamous cell carcinoma of the head and neck (SCCHN). In SCCHN, p63 isoform expression is very complex, with over-expression and isoform DeltaNp63 p63beta in many tumors. Until recently, little was known about the function of the different isoforms and elucidating DeltaNp63 distinctive properties of isoform DeltaNp63 will help to explain how they affect tumor biology.

With the gene expression profile SCCHN cells over-expressing isoform DeltaNp63 we identify the different effects of the three isoforms, with DeltaNp63beta become more effective in gene induction of DeltaNp63alpha and DeltaNp63gamma, while the most effective DeltaNp63gamma suppress gene expression. Thus, tumors express low levels even DeltaNp63beta or DeltaNp63gamma may have distinct clinicopathological characteristics essential for metastasis and response to therapy. Induction of cyclooxygenase-2 (Cox-2) shown by each isoform and data independently confirmed by quantitative RT-PCR and western blotting.

JBScreen Basic HTS
CS-203L	Jena Bioscience GmbH	96solutions	EUR 284.6

JBScreen Kinase HTS
CS-204L	Jena Bioscience GmbH	96solutions	EUR 468.98

JBScreen Detergents HTS
M-CS-525	MiTeGen	96 solutions	EUR 789
Description: JBScreen Detergents HTS

JBScreen Pentaerythritol HTS
CS-210L	Jena Bioscience GmbH	96solutions	EUR 468.98

JBScreen PEG/Salt HTS
CS-205L	Jena Bioscience GmbH	96solutions	EUR 298.08

JBScreen Nuc-Pro HTS
CS-209L	Jena Bioscience GmbH	96solutions	EUR 469.15

JBScreen Classic HTS I
CS-201L	Jena Bioscience GmbH	96solutions	EUR 284.6

JBScreen Classic HTS II
CS-202L	Jena Bioscience GmbH	96solutions	EUR 284.6

JBS Solubility Kit
CO-310	Jena Bioscience GmbH	1Kit	EUR 321.7

JBS Solubility Kit
M-CO-310	MiTeGen	1 Kit	EUR 368
Description: JBS Solubility Kit

JBScreen Wizard 1 & 2 HTS
CS-318	Jena Bioscience GmbH	96solutions	EUR 284.6

JBScreen Thermofluor SPECIFIC HTS
M-CS-333	MiTeGen	93 solutions	EUR 397
Description: JBScreen Thermofluor SPECIFIC HTS

JBScreen Thermofluor FUNDAMENT HTS
M-CS-332	MiTeGen	93 solutions	EUR 397
Description: JBScreen Thermofluor FUNDAMENT HTS

JBScreen Membrane 1 - 4 & JBScreen Detergents HTS (4 + 1 Kits)
M-CS-308	MiTeGen	4 + 1 Kits	EUR 2129
Description: JBScreen Membrane 1 - 4 & JBScreen Detergents HTS (4 + 1 Kits)

JBScreen Membrane HTS (1.7ml per well)
M-CS-310	MiTeGen	96 solutions	EUR 621
Description: JBScreen Membrane HTS (1.7ml per well)

JBScreen JCSG++ HTS L (1.7 ml per well)
M-CS-206L	MiTeGen	96 solutions	EUR 395
Description: JBScreen JCSG++ HTS L (1.7 ml per well)

JBScreen PACT++ HTS L (1.7 ml per well)
M-CS-207L	MiTeGen	96 solutions	EUR 395
Description: JBScreen PACT++ HTS L (1.7 ml per well)

JBScreen Plus HTS L (1.0 ml per well)
M-CS-507L	MiTeGen	96 solutions	EUR 883
Description: JBScreen Plus HTS L (1.0 ml per well)

JBScreen Basic HTS L (1.7 ml per well)
M-CS-203L	MiTeGen	96 solutions	EUR 377
Description: JBScreen Basic HTS L (1.7 ml per well)

JBScreen Kinase HTS L (1.7 ml per well)
M-CS-204L	MiTeGen	96 solutions	EUR 621
Description: JBScreen Kinase HTS L (1.7 ml per well)

JBScreen PEG/Salt HTS L (1.7 ml per well)
M-CS-205L	MiTeGen	96 solutions	EUR 395
Description: JBScreen PEG/Salt HTS L (1.7 ml per well)

JBScreen Nuc-Pro HTS L (1.7 ml per well)
M-CS-209L	MiTeGen	96 solutions	EUR 508
Description: JBScreen Nuc-Pro HTS L (1.7 ml per well)

JBScreen Pentaerythritol HTS L (1.7 ml per well)
M-CS-210L	MiTeGen	96 solutions	EUR 621
Description: JBScreen Pentaerythritol HTS L (1.7 ml per well)

JBScreen Classic HTS I L (1.7 ml per well) (PEG based)
M-CS-201L	MiTeGen	96 solutions	EUR 377
Description: JBScreen Classic HTS I L (1.7 ml per well) (PEG based)

Human Solubility Semaphorin-7A ELISA Kit
MBS3803073-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 6725

Human Solubility Semaphorin-7A ELISA Kit
MBS3803073-48StripWells	MyBiosource	48-Strip-Wells	EUR 550

Human Solubility Semaphorin-7A ELISA Kit
MBS3803073-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 3420

Human Solubility Semaphorin-7A ELISA Kit
MBS3803073-96StripWells	MyBiosource	96-Strip-Wells	EUR 765

Hi-Super Speed Sickle Kit (Solubility Te
MBP006-50TST	EWC Diagnostics	1 unit	EUR 15.32
Description: Hi-Super Speed Sickle Kit (Solubility Te

JBScreen LCP
CS-340	Jena Bioscience GmbH	4 x 24solutions	EUR 910.08

JBScreen LCP
M-CS-340	MiTeGen	4 x 24 solutions	EUR 1165
Description: JBScreen LCP

JBScreen Classic HTS II L (1.7 ml per well) (Ammonium Sulfate, MPD, Alcohol and Salt based)
M-CS-202L	MiTeGen	96 solutions	EUR 377
Description: JBScreen Classic HTS II L (1.7 ml per well) (Ammonium Sulfate, MPD, Alcohol and Salt based)

JBScreen Buffers
CS-214	Jena Bioscience GmbH	84solutions	EUR 298.08

JBScreen Buffers
M-CS-214	MiTeGen	84 solutions	EUR 395
Description: JBScreen Buffers

SMCC Plusâ„¢ *Enhanced water solubility, crosslinking efficiency and stability*
4503-5mg	AAT Bioquest	5 mg	EUR 222
Description: Compared to SMCC and sulfo-SMCC, SMCC Plus has enhanced water solubility and crosslinking efficiency.

JBScreen JCSG++ 1
CS-151	Jena Bioscience GmbH	24solutions	EUR 198.63

JBScreen JCSG++ 2
CS-152	Jena Bioscience GmbH	24solutions	EUR 198.63

JBScreen JCSG++ 3
CS-153	Jena Bioscience GmbH	24solutions	EUR 198.63

JBScreen JCSG++ 4
CS-154	Jena Bioscience GmbH	24solutions	EUR 198.63

JBScreen PACT++ 1
CS-161	Jena Bioscience GmbH	24solutions	EUR 198.63

JBScreen PACT++ 2
CS-162	Jena Bioscience GmbH	24solutions	EUR 198.63

JBScreen PACT++ 3
CS-163	Jena Bioscience GmbH	24solutions	EUR 198.63

JBScreen PACT++ 4
CS-164	Jena Bioscience GmbH	24solutions	EUR 198.63

JBScreen JCSG++ 1
M-CS-151	MiTeGen	24 solutions	EUR 263
Description: JBScreen JCSG++ 1

JBScreen JCSG++ 2
M-CS-152	MiTeGen	24 solutions	EUR 263
Description: JBScreen JCSG++ 2

JBScreen JCSG++ 3
M-CS-153	MiTeGen	24 solutions	EUR 263
Description: JBScreen JCSG++ 3

JBScreen JCSG++ 4
M-CS-154	MiTeGen	24 solutions	EUR 263
Description: JBScreen JCSG++ 4

JBScreen PACT++ 1
M-CS-161	MiTeGen	24 solutions	EUR 263
Description: JBScreen PACT++ 1

JBScreen PACT++ 2
M-CS-162	MiTeGen	24 solutions	EUR 263
Description: JBScreen PACT++ 2

JBScreen PACT++ 3
M-CS-163	MiTeGen	24 solutions	EUR 263
Description: JBScreen PACT++ 3

JBScreen PACT++ 4
M-CS-164	MiTeGen	24 solutions	EUR 263
Description: JBScreen PACT++ 4

JBScreen Basic 1
CS-121	Jena Bioscience GmbH	24solutions	EUR 188.18

JBScreen Basic 2
CS-122	Jena Bioscience GmbH	24solutions	EUR 188.18

JBScreen Basic 3
CS-123	Jena Bioscience GmbH	24solutions	EUR 188.18

JBScreen Basic 4
CS-124	Jena Bioscience GmbH	24solutions	EUR 188.18

JBScreen Basic 1
M-CS-121	MiTeGen	24 solutions	EUR 249
Description: JBScreen Basic 1

JBScreen Basic 2
M-CS-122	MiTeGen	24 solutions	EUR 249
Description: JBScreen Basic 2

JBScreen Basic 3
M-CS-123	MiTeGen	24 solutions	EUR 249
Description: JBScreen Basic 3

JBScreen Basic 4
M-CS-124	MiTeGen	24 solutions	EUR 249
Description: JBScreen Basic 4

JBScreen Kinase 1
CS-131	Jena Bioscience GmbH	24solutions	EUR 312.34

JBScreen Kinase 2
CS-132	Jena Bioscience GmbH	24solutions	EUR 312.34

JBScreen Kinase 3
CS-133	Jena Bioscience GmbH	24solutions	EUR 312.34

JBScreen Kinase 4
CS-134	Jena Bioscience GmbH	24solutions	EUR 312.34

JBScreen Wizard 1
CS-311	Jena Bioscience GmbH	48solutions	EUR 376.36

JBScreen Wizard 2
CS-312	Jena Bioscience GmbH	48solutions	EUR 376.36

JBScreen Kinase 1
M-CS-131	MiTeGen	24 solutions	EUR 414
Description: JBScreen Kinase 1

JBScreen Kinase 2
M-CS-132	MiTeGen	24 solutions	EUR 414
Description: JBScreen Kinase 2

JBScreen Kinase 3
M-CS-133	MiTeGen	24 solutions	EUR 414
Description: JBScreen Kinase 3

JBScreen Kinase 4
M-CS-134	MiTeGen	24 solutions	EUR 414
Description: JBScreen Kinase 4

JBScreen Classic 1
CS-101L	Jena Bioscience GmbH	24solutions	EUR 188.18

JBScreen Classic 2
CS-102L	Jena Bioscience GmbH	24solutions	EUR 188.18

JBScreen Classic 3
CS-103L	Jena Bioscience GmbH	24solutions	EUR 188.18

JBScreen Classic 4
CS-104L	Jena Bioscience GmbH	24solutions	EUR 188.18

JBScreen Classic 5
CS-105L	Jena Bioscience GmbH	24solutions	EUR 188.18

JBScreen Classic 6
CS-106L	Jena Bioscience GmbH	24solutions	EUR 188.18

JBScreen Classic 7
CS-107L	Jena Bioscience GmbH	24solutions	EUR 188.18

JBScreen Classic 8
CS-108L	Jena Bioscience GmbH	24solutions	EUR 188.18

JBScreen Classic 9
CS-109L	Jena Bioscience GmbH	24solutions	EUR 188.18

JBScreen Classic 10
CS-110L	Jena Bioscience GmbH	24solutions	EUR 188.18

JBScreen Plus Salts
CS-503	Jena Bioscience GmbH	24solutions	EUR 208.22

JBScreen Plus Salts
M-CS-503	MiTeGen	24 solutions	EUR 276
Description: JBScreen Plus Salts

JBScreen Membrane 1
CS-301L	Jena Bioscience GmbH	24solutions	EUR 361.5

JBScreen Membrane 2
CS-302L	Jena Bioscience GmbH	24solutions	EUR 361.5

JBScreen Membrane 3
CS-303L	Jena Bioscience GmbH	24solutions	EUR 312.34

JBScreen Membrane 4
CS-304L	Jena Bioscience GmbH	24solutions	EUR 361.5

JBScreen Plus Complete all 5 JBScreen Plus kits for a special price
M-CS-506	MiTeGen	5 Kits	EUR 1103
Description: JBScreen Plus Complete all 5 JBScreen Plus kits for a special price

JBScreen Plus Complete
CS-506	Jena Bioscience GmbH	5Kits	EUR 936.91

JBScreen Detergents 1
M-CS-521	MiTeGen	24 solutions	EUR 263
Description: JBScreen Detergents 1

JBScreen Detergents 2
M-CS-522	MiTeGen	24 solutions	EUR 263
Description: JBScreen Detergents 2

JBScreen Detergents 3
M-CS-523	MiTeGen	24 solutions	EUR 263
Description: JBScreen Detergents 3

JBScreen Detergents 4
M-CS-524	MiTeGen	24 solutions	EUR 263
Description: JBScreen Detergents 4

JBScreen JCSG++ 1 - 4
CS-155	Jena Bioscience GmbH	4Kits	EUR 670.49

JBScreen PACT++ 1 - 4
CS-165	Jena Bioscience GmbH	4Kits	EUR 670.49

JBScreen JCSG++ 1 - 4
M-CS-155	MiTeGen	4 Kits	EUR 858
Description: JBScreen JCSG++ 1 - 4

JBScreen PACT++ 1 - 4
M-CS-165	MiTeGen	4 Kits	EUR 858
Description: JBScreen PACT++ 1 - 4

JBScreen Buffers Xtreme
CS-215	Jena Bioscience GmbH	84solutions	EUR 298.08

JBScreen Plus Additives
CS-504	Jena Bioscience GmbH	24solutions	EUR 208.22

JBScreen Plus Volatiles
CS-505	Jena Bioscience GmbH	24solutions	EUR 208.22

JBScreen Buffers Xtreme
M-CS-215	MiTeGen	84 solutions	EUR 395
Description: JBScreen Buffers Xtreme

JBScreen Plus Additives
M-CS-504	MiTeGen	24 solutions	EUR 276
Description: JBScreen Plus Additives

JBScreen Plus Volatiles
M-CS-505	MiTeGen	24 solutions	EUR 276
Description: JBScreen Plus Volatiles

JBScreen Basic 1 - 4
CS-125	Jena Bioscience GmbH	4Kits	EUR 635.1

JBScreen PEG/Salt 1
CS-141	Jena Bioscience GmbH	24solutions	EUR 198.63

JBScreen PEG/Salt 2
CS-142	Jena Bioscience GmbH	24solutions	EUR 198.63

JBScreen PEG/Salt 3
CS-143	Jena Bioscience GmbH	24solutions	EUR 198.63

JBScreen PEG/Salt 4
CS-144	Jena Bioscience GmbH	24solutions	EUR 198.63

JBScreen Basic 1 - 4
M-CS-125	MiTeGen	4 Kits	EUR 813
Description: JBScreen Basic 1 - 4

JBScreen PEG/Salt 1
M-CS-141	MiTeGen	24 solutions	EUR 263
Description: JBScreen PEG/Salt 1

JBScreen PEG/Salt 2
M-CS-142	MiTeGen	24 solutions	EUR 263
Description: JBScreen PEG/Salt 2

JBScreen PEG/Salt 3
M-CS-143	MiTeGen	24 solutions	EUR 263
Description: JBScreen PEG/Salt 3

JBScreen PEG/Salt 4
M-CS-144	MiTeGen	24 solutions	EUR 263
Description: JBScreen PEG/Salt 4

JBScreen Plus Chaotropic
M-CS-502	MiTeGen	24 solutions	EUR 276
Description: JBScreen Plus Chaotropic

JBScreen Kinase 1 - 4
CS-135	Jena Bioscience GmbH	4Kits	EUR 1054.13

JBScreen Nuc-Pro 1
CS-181	Jena Bioscience GmbH	24solutions	EUR 312.77

JBScreen Nuc-Pro 2
CS-182	Jena Bioscience GmbH	24solutions	EUR 312.77

JBScreen Nuc-Pro 3
CS-183	Jena Bioscience GmbH	24solutions	EUR 312.77

JBScreen Nuc-Pro 4
CS-184	Jena Bioscience GmbH	24solutions	EUR 312.77

JBScreen Wizard 1 & 2
CS-315	Jena Bioscience GmbH	2Kits	EUR 714.44

JBScreen Kinase 1 - 4
M-CS-135	MiTeGen	4 Kits	EUR 1349
Description: JBScreen Kinase 1 - 4

JBScreen Nuc-Pro 1
M-CS-181	MiTeGen	24 solutions	EUR 414
Description: JBScreen Nuc-Pro 1

JBScreen Nuc-Pro 2
M-CS-182	MiTeGen	24 solutions	EUR 414
Description: JBScreen Nuc-Pro 2

JBScreen Nuc-Pro 3
M-CS-183	MiTeGen	24 solutions	EUR 414
Description: JBScreen Nuc-Pro 3

JBScreen Nuc-Pro 4
M-CS-184	MiTeGen	24 solutions	EUR 414
Description: JBScreen Nuc-Pro 4

JBScreen Plus Kosmotropic
CS-501	Jena Bioscience GmbH	24solutions	EUR 208.22

JBScreen Plus Kosmotropic
M-CS-501	MiTeGen	24 solutions	EUR 276
Description: JBScreen Plus Kosmotropic

JBScreen Classic 1 - 5
CS-112L	Jena Bioscience GmbH	5Kits	EUR 845.64

JBScreen Classic 6 - 10
CS-113L	Jena Bioscience GmbH	5Kits	EUR 845.64

JBScreen Classic 1 - 10
CS-114L	Jena Bioscience GmbH	10Kits	EUR 1566.67

JBScreen Classic 1 - 5
M-CS-112L	MiTeGen	5 Kits	EUR 1082
Description: JBScreen Classic 1 - 5

JBScreen Classic 6 - 10
M-CS-113L	MiTeGen	5 Kits	EUR 1082
Description: JBScreen Classic 6 - 10

JBScreen Classic 1 - 10
M-CS-114L	MiTeGen	10 Kits	EUR 2005
Description: JBScreen Classic 1 - 10

JBScreen Membrane 1 - 4
CS-309	Jena Bioscience GmbH	4Kits	EUR 1084.5

JBScreen Pentaerythritol 1
CS-191	Jena Bioscience GmbH	24solutions	EUR 361.5

JBScreen Pentaerythritol 2
CS-192	Jena Bioscience GmbH	24solutions	EUR 312.34

JBScreen Pentaerythritol 3
CS-193	Jena Bioscience GmbH	24solutions	EUR 312.34

JBScreen Pentaerythritol 4
CS-194	Jena Bioscience GmbH	24solutions	EUR 312.34

JBScreen Thermofluor SPECIFIC
CS-333	Jena Bioscience GmbH	93solutions	EUR 299.89

JBScreen PEG/Salt 1 - 4
CS-145	Jena Bioscience GmbH	4Kits	EUR 670.49

JBScreen PEG/Salt 1 - 4
M-CS-145	MiTeGen	4 Kits	EUR 858
Description: JBScreen PEG/Salt 1 - 4

JBScreen Nuc-Pro 1 - 4
CS-185	Jena Bioscience GmbH	4Kits	EUR 1054.62

JBScreen Nuc-Pro 1 - 4
M-CS-185	MiTeGen	4 Kits	EUR 1349
Description: JBScreen Nuc-Pro 1 - 4

JBScreen Pentaerythritol 1 - 4
CS-195	Jena Bioscience GmbH	4Kits	EUR 1084.5

JBScreen Pentaerythritol 1-4
M-CS-195	MiTeGen	4 Kits	EUR 1349
Description: JBScreen Pentaerythritol 1-4

JBScreen Classic 7 (MPD based)
M-CS-107L	MiTeGen	24 solutions	EUR 249
Description: JBScreen Classic 7 (MPD based)

Mouse Solubility T Cell Immunoglobulin-and Mucin-Domain-Containing Molecule-3 ELISA Kit
MBS3807468-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 6725

Mouse Solubility T Cell Immunoglobulin-and Mucin-Domain-Containing Molecule-3 ELISA Kit
MBS3807468-48StripWells	MyBiosource	48-Strip-Wells	EUR 550

Mouse Solubility T Cell Immunoglobulin-and Mucin-Domain-Containing Molecule-3 ELISA Kit
MBS3807468-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 3420

Mouse Solubility T Cell Immunoglobulin-and Mucin-Domain-Containing Molecule-3 ELISA Kit
MBS3807468-96StripWells	MyBiosource	96-Strip-Wells	EUR 765

JBScreen Classic 10 (Salt based)
M-CS-110L	MiTeGen	24 solutions	EUR 249
Description: JBScreen Classic 10 (Salt based)

JBScreen Classic 2 (PEG 4000 based)
M-CS-102L	MiTeGen	24 solutions	EUR 249
Description: JBScreen Classic 2 (PEG 4000 based)

JBScreen Classic 3 (PEG 4000+ based)
M-CS-103L	MiTeGen	24 solutions	EUR 249
Description: JBScreen Classic 3 (PEG 4000+ based)

JBScreen Membrane 4 (MPD, & Salt based)
M-CS-304L	MiTeGen	24 solutions	EUR 414
Description: JBScreen Membrane 4 (MPD, & Salt based)

No direct binding of DeltaNp63 to Cox-2 promoter could be seen, can not be evidence for Cox-2 induction as a consequence of activated NF-kappaB pathway responses found. Known as Cox-2 inhibiting response to radiotherapy in patients with SCCHN, the data shows an additional mechanism through which DeltaNp63 act to promote cell survival and affect the therapeutic response SCCHN. MIAME-compliant data has been stored in the database MIAME Express